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Fig. 2. The multiple neural tubes of Tbx6 mutant embryos each recruit a
PNVP. (A,B) Diagram of a transverse section through the caudal region of a
wild-type (A) and Tbx6 homozygous mutant (B) embryo depicting the
differences in Tbx6 mutant embryos. Note that somitic tissue (yellow)
does not form in the Tbx6 mutants, but ectopic neural tubes (blue)
form on both sides of the main neural tube (blue). (C,D) Transverse sections
through the posterior trunk of 10.5 dpc PECAM-stained wild-type (C) and
Tbx6 mutant (D) embryos. The PNVP around the central neural tube is
present in both embryos (arrows in C,D), and the ectopic neural tubes (denoted
with asterisks in the Tbx6 mutant embryo) are also surrounded by a
vascular plexus (arrowheads in D). Scale bar: 70 µm in C,D.
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