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Fig. 9. Neural tube patterning of blood vessels – a model. (A) Diagram showing cross-sectional view of a mouse embryo at 8.5 dpc. The boxed area is enlarged in B-D. (B) Initially, the presomitic mesoderm does not contain committed vascular precursor cells. (C) A VEGF-independent signal induces FLK1 expression in a subset of presomitic mesoderm cells. (D) FLK1 expressing angioblasts are now competent to respond to the neural tube-derived VEGFA containing signal. The angioblasts now express additional vascular markers, such as FLT1, and they migrate and assemble the PNVP. Other unidentified signals emanating from the neural tube may also contribute to PNVP patterning in vivo. NT, neural tube; NC, notochord; PSM, presomitic mesoderm; IM, intermediate mesoderm; LPM, lateral plate mesoderm.





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