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Fig. 3. Expression of Zic3 mRNA on cross sections of embryonic chick eye.
In situ hybridization experiments were performed on the cryosections of
embryonic chick eye at various stages: (A) E4.5; (B) E6; (C,D) E9; (E,F) E16.
Note that Zic3 mRNA expression is in a periphery-high, center-low
gradient at E4.5 and E6 (A,B). At E9, most of Zic3 expression is
confined to the retinal periphery (labeled `P' in C,D). Zic3 is also
highly expressed in the ciliary margin area (C,E,F). At E16, Zic3
expression can be barely detected inside the retina while at a high level at
the ciliary margin (E,F). C, center of the retina; P, periphery of the retina;
R, retina; CM, ciliary margin. Arrowhead in C indicates the remaining
undifferentiated cells located in the inner nuclear layer that are weakly
expressing Zic3 mRNA at the retinal center. Scale bars: 100 µm in
A,B,D-F; 400 µm in C.
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