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Fig. 2. Sotv and Botv are members of the Drosophila EXT family of tumor suppressors. (A) Structures and mutations of Sotv and Botv. Sotv and Botv are putative type II transmembrane proteins. Three mutations of botv and sotv are shown in green bars (except sotv44, which harbors a G to A transition at the start codon). (B) Phylogenetic tree of Drosophila, mouse (m), and human (h) EXT family proteins. Ttv, Sotv and Botv are the Drosophila EXT1, EXT2 and EXTL3 proteins, respectively. (C) Sequence comparison of Ttv, Sotv and Botv. Identical residues are highlighted (light red) and consensus residues are boxed. A conserved nucleotide sugar-binding motif DXD is found at the C-terminal portion of all three proteins and is boxed (blue). The sequence alignment and phylogenetic tree were generated using Lasergene software with the Jotun Hein method.





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