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Fig. 6. Ontogeny of p63 in female reproductive tract of DES-exposed mice. P63 was detected by IHC in developing [postnatal days 5 (A-C), 7 (D,E) and 10 (F)] and adult (P60, G) mouse female reproductive tract treated with oil (A) or DES (B-G). Green arrows indicate p63-negative Müllerian-vaginal and cervical epithelial cells. DES disrupted p63 expression in Müllerian vagina and cervix via ERa [compare oil-treated ER{alpha}+/+ (A), DES-treated ER{alpha}+/+ (B) and DES-treated ER{alpha}–/–groups (C)]. Although most cervicovaginal epithelial cells expressed p63 by 2 days after the last DES-treatment (D), a small number of p63-negative columnar epithelium persisted at P7 (D) and P10 (F) (green arrows) in the Müllerian vagina and cervix, and developed into adenosis in adulthood (G). When DES-treatment was extended from birth to P7 (E), formation of p63-positive basal layer was largely inhibited at P7 (compare D with E). Scale bar: 50 µm.





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