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Fig. 4. Schematic diagram of Axin, showing its binding sites for various interacting proteins, including Arrow/Lrp5. How Axin binds to Arrow/Lrp5 was mapped only via yeast two-hybrid assays and is not well defined. Axin-Lrp6 binding has not been mapped. Known binding sites for various Axin-binding proteins are depicted with square brackets on top. For Axin-Arrow/Lrp5 binding, the DIX domain and possibly the domains preceding it appear to be required (marked by the green line), whereas the RGS domain may be inhibitory (marked by the red line) (Mao et al., 2001b; Tolwinski et al., 2003). The broken green or red line indicates that the domain boundary has not been defined by mapping. The question mark indicates some ambiguity/inconsistency of the two mapping studies.





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