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Fig. 6. The putative function of ATO proteins and NGN proteins during neuronal lineage development in Drosophila and vertebrates. (A) Both ATO proteins and NGN proteins may be specifying early neural progenitors (NPCs) in flies and vertebrates, respectively, using divergent mechanisms. N and G are neuronal and glial precursors, respectively. (B) In vertebrates, NGN proteins may specify neuronal, rather than neural, precursor cells. In this model, it is not known which genes specify neural precursor cells. (C) ATO proteins and NGN proteins use different genetic pathways to regulate Notch signalling and neural and/or neuronal precursors. X and Y refer to different unknown factors that mediate the synergy between ATOs and SENS on the one hand, and NGNs and MyT1 on the other.





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