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Fig. 8. Model for assembly and function of an aly-class protein complex at target promoters. Aly and Comr may be imported into the nucleus together or may only form a stable complex in the nucleus. Either protein alone remains in the cytoplasm. Topi and Achi/Vis proteins would enter the nucleus independently. These putative DNA-binding proteins would recognize specific sequences at target promoters, and once bound they would together recruit the Aly/Comr complex to these promoters. Alternatively, Topi and Achi/Vis could assemble with Aly/Comr in the nucleus, and this entire complex would then bind target promoters. This complex would then recruit the NURD histone deacetylase chromatin remodelling complex and promote transcription.





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