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Fig. 7. Paraxial mesoderm targeted expression of wild-type Cdc25 disrupts
convergent extension. (A) Dorsal and posterior views of embryos unilaterally
injected with 100 pg of the indicated Cdc25 plasmid DNA. Embryos were allowed
to develop until stage 19 before being processed for GFP in situ analysis.
Cells expressing GFP-Cdc25 stain blue. WT [wild type (active)] and PD
[phosphatase-dead (inactive)] forms of Cdc25A or Cdc25C. Lateral limits of
GFP-Cdc25 positive cells are indicated by broken lines. Arrows indicate the
lack of a somatic ridge. (B) Dorsal, anterior and sectioned views of embryos
unilaterally injected and treated as in A, except 300 pg of Cdc25A plasmid DNA
was used. Arrow indicates somitic ridge.
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