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Fig. 4. Shh and Ptc expression. In situ hybridisation was performed on the dorsal
skin of (A-D) untreated wild-type mouse with anagen follicles, (E-H) D2 or
(I-L) D4 transgenic mice treated with 4OHT for 7 days, and (M-P) on the dorsal
paw skin of D4 transgenic mice treated with 4OHT for 7 days. (B,F,J,N)
Dark-field views of Shh in situ hybridisations in A,E,I,M, respectively.
(D,H,L,P) Dark-field views of Ptc in situ hybridisations in C,G,K,O,
respectively. Arrows in B indicate asymmetric Shh expression in the bulb of
the hair follicle, while the arrow in D indicates more uniform Ptc expression
in the bulb. Arrows in F,J show Shh expression in the outgrowths arising from
the permanent portion of the follicles. Arrowheads in J show abnormal
symmetrical expression of Shh in the bulb of the hair follicle and the
asterisk in N indicates Shh expression in epithelial downgrowths in the
interfollicular epidermis. Scale bars: 100 µm.
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