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Fig. 2. Tbx1/TBX1 suppresses NeuroD expression in the otocyst. Lateral surface views of whole-mount hybridized embryos arrayed by stage, genotype, and hybridization probe. All transgenic (Tg) embryos shown are of Tg+/+ genotype. Mottled otocyst NeuroD signals are epithelial; dense signals apposed to the otocyst indicate the VIIIth ganglion. Asterisks mark the facial ganglion. Arrows in G,H,I mark heightened/ectopic NeuroD expression in Tbx1+/– otocysts. p, petrosal ganglion. m, Tbx1-positive mesenchyme. Scale bar: 100 µm applies to all panels.





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