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Fig. 7. Otocyst Bmp4 expression is sensitive to Tbx1 gene copy number. (A-F) 30 µm transverse cryosections of Bmp4 hybridized embryos at the level of the anterior stripe (arrows in B). Asterisk in C indicates the absence of a definitive anterior stripe in E11 Tbx1+/– otocysts. Arrowheads in F indicate mesenchymal Bmp4 signal of low intensity compared to wild type.





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