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Fig. 9. Summary. (A) Gene expression and predicted fates of the E10.5 otocyst lateral wall. Specification of neural and sensory organ fates appears to involve both reciprocal compartmentalization (Tbx1/Bmp4/Otx1 vs. bHLH gene expression domain) and change in competence of a pluripotent progenitor field over time (bHLH gene/Lfng domain). (B) Neural and particular sensory organ fates may be specified in parallel through opposing actions of Tbx1 on gene expression. Question marks indicate potential relationships that are unsubstantiated by genetic analyses.





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