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Fig. 4. Altered proliferation of hair follicle cells in Hair-Bmpr1a KO
mice. Phosphorylated histone (PH) immunostaining signals exhibit dividing
epithelial cells of HFs from P30 control mice (A). P30 Hair-Bmpr1a KO
mice showed that PH-positive cells were located abnormally in hair canals of
HF (B). Older (10-month-old) Hair-Bmpr1a KO mice showed a
significantly reduced index of PH immunosignals (D) than did control mice (C).
BrdU incorporation in Hair-Bmpr1a KO mice (F) was severely reduced
compared with control mice (E). The number of PH-positive cells per HF was
counted in P14, P30 and older mice (n=24 per group) (G). Data are
given as mean±s.e.m.; *P<0.05; Student's t-test.
Scale bars: 100 µm in A (left panel), B (left panel) and C-F; 50 µm in A
(right panel) and B (right panel).
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