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Fig. 1. Analysis of the denticle belt fusion phenotype (for example, see arrow in A) of spitz group mutants. (A) Penetrance (percentage of embryos having at least one fusion) of the denticle belt fusion phenotype of null mutations in different spitz group genes. The denticle belts of each parasegment are labelled to the right of the wild-type cuticle for reference. Expression of a dominant-negative form of the EGFR throughout the epidermis resulted in denticle belt fusions, confirming that this phenotype was indeed the result of reduced EGFR signalling. Note that single minded, while being a member of the spitz group, is not an EGFR component: consistent with this, mutants do not show denticle fusions. (B) Distribution of denticle belt fusions observed in each parasegment (analysis of a rhomboid-1 mutant is shown but other spitz group genes showed similar spectra). Denticle belt fusions were observed in all parasegments, but occurred most frequently between the T3 and A1, A4 and 5, and A5 and 6 denticle belts.





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