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Fig. 4. Expressivity of the denticle belt fusion phenotype in different
spitz group mutants. Expressivity reflects the severity of the
denticle belt fusion phenotype, and is measured as the number of fusions per
embryo. Note that one denticle belt fusion results from the midline joining of
two denticle belts; as such, a total of ten fusions are possible in a single
embryo since there are a total of 11 (three thoracic and eight abdominal)
denticle belts. (A) An example of a spitz null embryo displaying four
denticle belt fusions. (B) The expressivity of various spitz group
genes was analysed, which revealed that most mutant embryos contained between
one and three fusions, but never more than five of the 10 possible fusions.
(C) rhomboid-1 vein double mutant embryos are more severely affected
than spitz group embryos, and only one in three could be analysed for
ventral epidermal patterning. (D) A rhomboid-1 vein double mutant
dramatically increased the expressivity (but not penetrance) of the fusion
phenotype compared to that of rhomboid-1 alone.
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