|
|
|
|
|
|
|
||||
| Home Help Feedback Subscriptions Archive Search Table of Contents | ||||
|
Fig. 4. Glomerular abnormalities in adult endothelium-specific Pdgfb
knockouts. H/E staining of 3-week-old kidneys revealed an increased glomerulus
diameter (A,B) and capillary loop diameter (C) in lox/– mice compared
with controls. Capillary diameters of the lox/– animals differ
significantly from those of the control group (P<0.005). The
relative distribution of the maximal capillary diameter in the control and
endothelium-specific Pdgfb knockout groups is shown. Measured
diameters have been corrected to the closest 1 µm to yield an illustrative
figure. PAS staining of adult kidneys did not reveal signs of pathology at the
age of 6 months (D,F) or >1 year (E,G). Glomerular cell count and matrix
volume were comparable in the various genotypes, Scale bar: 10 µm). (H,I)
Urine albumin levels were increased in lox/– mice that were more than a
year old (P<0.05), but not in 6-month-old lox/– mice
(P>0.05). Glomerular PDGFB protein levels (J,K) were reduced in
lox/– mice and the reduction was significant (P<0.005) in
mice that were more than a year old. Bars represent levels (±s.d.) of
albumin secretion (H,I) and PDGFB protein (J,K).
|
