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Fig. 6. Reduced PC recruitment to brain capillaries in endothelium-specific
Pdgfb knockouts. Whole-mount ß-gal staining of PCs in the
midbrain. (A-D) Ventricular view of entire midbrain hemispheres; (E-H)
Distribution of PCs (nuclear staining) in the subventricular zone (SVZ) plexus
of the hemisphere. Black arrowheads indicate extensively dilated vessels; red
arrowheads indicate focal hemorrhages. Note the dramatic PC deficiency in
Pdgfb–/– tissue (B,F,J) and the intermediate
PC densities in lox/– tissue (C,D,G,H,K,L). (I-L) Sections (
100
µm thick) of midbrain hemispheres, with the meningeal surface to the left
and the ventricular surface to the right. The distribution of
ß-gal-positive PCs along the radial vessels (rad) is seen. In the
lox/– embryos (K,L) many radial branches completely lack
ß-gal-positive PC coverage (green arrowheads), as in the –/–
embryos (J), whereas other branches show normal coverage (white
arrowheads).
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