spacer gif spacer gif spacer gif spacer gif spacer gif
QUICK SEARCH:   [advanced]


spacer gif
     Home     Help     Feedback     Subscriptions     Archive     Search     Table of Contents    

Right arrow Help viewing high resolution images
Right arrow Return to article
(Downloading may take up to 30 seconds.
If the slide opens in your browser, select File -> Save As to save it.)
Click on image to view larger version.



Fig. 3. Iron deficiency anemia at birth and iron accumulation in young adults in Pcm mutant mice. (A) Peripheral blood smear remarkable for hypochromic, microcytic red blood cells in Pcm/Pcm mice at P0. Wright-Giemsa stain. (B) Prussian Blue staining of P0 liver sections reveals decreased parenchymal liver iron in Pcm/Pcm mice. (C) Quantification of total iron at P0 demonstrates organismal iron deficiency in Pcm mutant pups. (D) Prussian Blue staining of sections of 12-week-old liver shows numerous localized iron deposits in Pcm/Pcm mice. (E) Hepatic iron content significantly elevated by 12 weeks of age in Pcm/Pcm mice. (F) Decreased serum iron levels in Pcm mutants compared with wild type. Asterisk, P<0.05; double asterisk, P<0.01; triple asterisk, P<0.001.





Right arrow Return to article