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First published online March 30, 2004

Development 131, 804e (2004)
© The Company of Biologists Limited
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In this issue

It's a hormonal thing

When times get bad – if food is limited, for example – Caenorhabditis elegans larvae enter the dauer larval stage 3 for several months, rather than racing through the normal larval stage 3 in a few hours. Attenuation of daf-2 insulin/IGF or daf-7 TGFß-like signaling pathways causes developmental arrest at the dauer stage – as does loss of function of DAF-9, a cytochrome P450 related to steroidogenic hydroxylases. Two papers in this issue implicate DAF-9 in the production of important hormonal signals that regulate dauer diapause. On p. 1765, Gerisch and Antebi show that daf-9 overexpressed constitutively in the hypodermis – the tissue in which endogenous daf-9 expression is most visibly regulated by environmental cues – acts systemically to rescue the dauer phenotypes of daf-9, daf-2 and daf-7 mutants. This indicates that DAF-9 acts downstream of insulin/IGF and TGFß signaling during dauer regulation. Mak and Ruvkun present similar results on p. 1777, and both research teams show that hypodermal daf-9 expression is strictly dependent on daf-12, the nuclear receptor for the hormone produced by DAF-9.


Related articles in Development:

Hormonal signals produced by DAF-9/cytochrome P450 regulate C. elegans dauer diapause in response to environmental cues
Birgit Gerisch and Adam Antebi
Development 2004 131: 1765-1776. [Abstract] [Full Text]  

Intercellular signaling of reproductive development by the C. elegans DAF-9 cytochrome P450
Ho Yi Mak and Gary Ruvkun
Development 2004 131: 1777-1786. [Abstract] [Full Text]  




This Article
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