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First published online March 30, 2004

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Heard the news about Tbx1?

Inner ear sensory organs, which mediate balance and hearing in mammals, and the VIIIth cranial ganglion neurons, which innervate them, are derived from the otocyst, an epithelial vesicle formed by invagination of the otic placode. Raft et al. now report that Tbx1 differentially controls sensory organ and neural fate specification in the otocyst (see p. 1801). Tbx1 is a member of the T-box family of DNA-binding transcriptional regulators that control diverse aspects of embryogenesis, including cell-fate specification, in many organisms. The researchers show that while overexpression of Tbx1 suppresses neurogenesis in the mouse otocyst epithelium, Tbx1 loss of function results in ectopic neural precursor generation and sensory organ dysmorphogenesis. Together with expression data, these results indicate that Tbx1 acts as a selector gene to specify regional identity in the otocyst.

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Related articles in Development:

Suppression of neural fate and control of inner ear morphogenesis by Tbx1

Steven Raft, Sonja Nowotschin, Jun Liao, and Bernice E. Morrow
Development 2004 131: 1801-1812. [Abstract] [Full Text]  

This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Related articles in Development Similar articles in this journal Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via Google Scholar Google Scholar Search for Related Content Social Bookmarking                         What's this?