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Fig. 3. Histological analysis of tissue-specific knock-out gonads at E18.5. (A-C)
Control females. In contrast to control males (D-F), Sox9 knock-out
animals show somewhat irregular and poorly differentiated sex cords (G, and
arrow in H). Next to quiescent gonocytes (arrows in I), several gonocytes in
meiotic prophase could be detected (asterisks), suggesting differentiation of
these primordial germ cells along the female pathway (compare with C). (J-L)
Mice homozygous for the Sox8/Sox8 knock-out allele, but without the
Sox9 tissue-specific knock-out showed normal sex cord formation and
no sign of meiosis. By contrast, embryos heterozygous for the Sox8
knock-out and homozygous for the Sox9 knock-out (M-O) often showed
complete sex reversal (compare with female development in A-C). See
Table 1 for the frequencies of
the sex reversal phenotype.
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