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Fig. 8. Immunofluorescent analysis of Sox8, Sox9 double knock-out mice.
Double staining of E15.5 gonads for Mis (red) and Sox9 (green). (A,B) Control
ovary and testis. Sf1:Cre; Sox9/Sox9 knock-out mice (C,D) showed a
varying degree of sex cord formation (D shows the most severe phenotype
observed during this analysis). (E,F) Control ovary and testis. By contrast,
Sox8/Sox9 double knock-out mice showed a much more severe phenotype,
often resulting in complete sex reversal (G,H). The formation of sex cords and
the expression of Mis was restricted to cells expressing Sox9. Note,
embryos shown in A-D were derived from a different litter to those shown in
E-H.
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