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Fig. 2. tbx-37 and tbx-38 map positions and T-box DNA-binding domains. (A) Region from the right arm of chromosome III deleted by both zuDf1 and zuDf3. Bold lines indicate DNA lacking in the various deficiency strains used. Terminal arrowheads indicate that the deficiency extends further than shown, black and white circles indicate defined and approximate deficiency breakpoints, respectively. The physical positions of listed genes are indicated in Mb according to the Wormbase web site (http://www.wormbase.org, release WS100, 2003). (B) The highly conserved T-box DNA-binding domain from mouse Tbx6 is shown with the corresponding domains from the C. elegans TBX-37, TBX-38 and TBX-8 proteins. The DNA-binding domains of TBX-37 and TBX-38 are nearly identical; residues shared between either of these proteins and TBX-8 or Tbx6 are shown in bold. Mutations in tbx-37 are as follows with base changes underlined: zu464 [glycine to glutamic acid change in DNA-binding domain (asterisk); GCCTCCGAATTC], zu466 (premature stop in exon 4; GGAGCTTAAAAT) and zu467 (5' splice site in intron 3; CAGATTGGGATT). Mutations in tbx-38 are as follows: zu463 [3' splice site in intron 2 (double asterisk); TTTCCAAAAC], zu460 [deletion beginning at 5' splice site in intron 2 (double asterisk); AGGTTT//GACATA]; and zuDf5 (deletion that removes tbx-38 and the flanking genes).

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