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Fig. 7. Model for the establishment of the MH neurogenesis pattern. The entire MH
territory is competent to become a proneural cluster. Within this domain
(left), the activities of Ngn1 and Coe2, their positive crossregulation of
expression and their sensitivity to the lateral inhibition machinery are
crucial elements controlling the commitment of progenitors towards neuronal
differentiation. At the MHB, however, Her5 exerts an early inhibition on the
expression of ngn1 and coe2, preventing the specification of
a proneural cluster and the initiation of neurogenesis in this location,
generating the IZ (right panel). As a result, neurogenesis is spatially
restricted to the vcc and r2 (left panel).
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