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Fig. 2. Abnormalities in the adult brain of En1cre/+; Otx2flox/flox mutants. (A-D) Midbrain and cerebellum of adult En1cre/+ and En1cre/+; Otx2flox/flox mice are compared in dorsal view (A), or in sagittal (B,C) and frontal (D) Nissl-stained sections. (E) High magnification of the area demarcated by a square in (D). (F) Th immunostaining of the DA area in a frontal section close to (D). The arrows in B indicate the approximate position of frontal sections. InC, inferior colliculus; SuC, superior colliculus; OM oculomotor nucleus; RN, red nucleus; SN, substantia nigra; VTA, ventral tegmental area.





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