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Fig. 6. Lack of Otx2 and increased expression of Shh affect the expression of
Nkx6.1 and Nkx2.2. (A-L) Shh (A,D,G,J), Nkx6.1 (B,E,H,K) and Nkx2.2 (C,F,I,L)
immunodetection in the ventral midbrain of E10.5 and E12.5
En1cre/+ and En1cre/+;
Otx2flox/flox embryos (A-F), in the rostral hindbrain of
E12.5 En1cre/+ embryos (G-I), and in the ventral midbrain
of E12.5 Otx1cre/+; Otx2flox/–
embryos (J-L). The arrows in B,E,K indicate the ventral neuroepithelium where
Nkx6.1 expression is lost, and the arrows in C,F indicate the ventral
expansion of the Nkx2.2 domain. fp, floor plate; ABB, alar-basal boundary.
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