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Fig. 7. Regulation of Wnt7a, Hoxa10 and Hoxa11 genes is
deficient in the Wnt5a mutant during estrous. Genotypes are indicated
at the top and in situ probes on the left. (A) Control and
Wnt5a-/- grafts were grown for 3 weeks in a cycling host
that was sacrificed at diestrus when the level of circulating estrogen is low.
Wnt7a and Hoxa genes expression is normal in the
Wnt5a-/- graft. Note the expected lack of expression of
Hoxa10 and Hoxa11 genes in the anterior mutant FRT, i.e.
tubular and ostium (infundibulum) region of the oviduct. Lines in the
Hoxa10 photographs delineate the limit between the epithelium and the
stroma. (B) As in A but the host was sacrificed at late proestrus when the
level of circulating estrogen is high. Wnt7a and Hoxa10 and
Hoxa11 are downregulated in the control wild-type and
Wnt5a+/– grafts but not in the
Wnt5a-/- grafts.
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