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Fig. 10. Expression of Col2a1, Ihh, and Pthr1, in the E18.5
humerus. In Vegfa conditional knockout (CKO) mice (A), areas of
increased proliferation (square) can be seen surrounding areas of cell death;
square in A seen at higher magnification in B, arrowheads indicate
proliferating cells. Col2a1 expression is seen throughout the
cartilage in unaffected mice (C) while in Vegfa CKO (D) mice
Col2a1 expression is lacking in the center of the cartilage
(arrowhead). Ihh and Pthr1 expression in the unaffected
humerus (E,G) is restricted to a narrow strip of prehypertrophic cells. In the
Vegfa CKO growth plate the domain of expression of both Ihh
and Pthr1 is expanded (F,H).
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