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Fig. 3. Reduced removal of terminally differentiated chondrocytes in Vegfa conditional knockout (CKO) bones. Histological sections of E16.5 unaffected (A) and Vegfa CKO (B) humerus show the presence of an expanded hypertrophic zone in the Vegfa CKO growth plate (defined by brackets). Col2a1 expression is seen throughout the cartilage anlagen in both unaffected (C) and Vegfa CKO (D) mice. In unaffected (E) mice Col10a1 expression is seen in the hypertrophic zone (bracket) while in Vegfa CKO (F) mice, Col10a1 expression is seen only in part of the hypertrophic zone (bracket), suggesting that some of the hypertrophic chondrocytes are differentiated into terminal hypertrophic chondrocytes. Osp expression is seen in the last row of terminally differentiated hypertrophic chondrocytes and extensively in the osteoblasts under the growth plate in the unaffected mice (G), while in the Vegfa CKO growth plate, Osp expression is detected in several rows of terminally differentiated hypertrophic chondrocytes (H).





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