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Fig. 5. Apoptosis in Vegfa conditional knockout (CKO) bones. Histological
sections through the center of E18.5 unaffected (A,C) and Vegfa CKO
(B,D) humerus. Areas within the squares in A and B are shown at high
magnification in C and D. In the affected epiphysis (D), the presence of
apoptotic cells with shrunken cytoplasm and condensed nuclei is observed.
TUNEL assay of E18.5 unaffected (E) and Vegfa CKO (F) humerus and
Vegfa CKO tibia and femur (G) shows strong TUNEL-positive signals in
regions of apoptotic cells (arrowheads) in the Vegfa CKO bones (E and
F are serial sections of A and B, while G is serial section of
Fig. 4 D). Histological
sections of E16.5 Prx1/Vegfa CKO scapula and humerus show
misshapen bones with extensive regions of dead cells (H, arrowheads).
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