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Fig. 1. sAPP-binding sites are present on SVZ cells. Single (A-D,F,G,I,J,L-N) or double (E,H,K) immunofluorescent stainings of frontal sections through the SVZ. (A) SVZ cells express APP. The SVZ is outlined by two white lines. (B) SVZ cells express sAPP-binding sites. (C-E) sAPP-binding sites (D) are present on EGFR immunopositive SVZ cells (C). (F-H) sAPP-binding sites (G) are present on PSA-NCAM immunoreactive neuroblasts (F). (I-K) S100 immunoreactive astrocytes (arrowheads) and ependymal cells (arrow) (I) do not express sAPP binding sites (J). (L-N) L1-binding sites are detected by the same technique in the SVZ (L), hippocampus (M) and cortex (N). St, striatum; LV, lateral ventricle. Scale bars: 10 µm.





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