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Fig. 4. sAPLP2 is functionally redundant with sAPP in the SVZ. (A) SVZ cells do not
express sAPLP1 binding sites. (B) SVZ cells express sAPLP2 binding sites. (C,
left panel) APLP1 immunoblotting showing APLP1 expression in the SVZ. (C,
right panel) APLP2 immunoblotting of the SVZ from sense (S) or antisense (AS)
APLP2 oligonucleotides infused mice reveals a 30% reduction in APLP2 levels in
AS. (D) Augmentation of sAPLP2 concentration upon sAPLP2-Fc infusion increases
the number of EGF-responsive NS progenitors in the SVZ, whereas reduction of
APLP2 synthesis by antisense oligonucleotide infusion decreases their number.
Results are shown as mean±s.e.m. of six infused mice. Scale bars: 10
µm
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