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Fig. 6. TEM analysis of IFM ultrastructural morphology reveals muscle fiber
degeneration, mitochondrial defects and apoptosis in parkin mutants 2
days after eclosion. (A) Control animals have well organized uniform muscle
architecture and electron dense mitochondria. (B) parkin mutant
muscle fibers are fragmented (arrow) and mitochondria show loss of christae
(asterisk). These phenotypes are rescued with dpkR (C), but not with
dpkSR transgenes (D). (E) Control animals do not show any signs of
muscle death; however, parkin mutant IFMs (F) show clear signs of
apoptosis, including chromatin condensation and nuclear envelope breakdown
(arrows).
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