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First published online April 22, 2004

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Roundabout glomerular patterning

In the olfactory system of Drosophila, sensory neurons synapse with projection neurons in specifically positioned structures called glomeruli. The relatively conserved pattern of olfactory glomeruli between individuals suggests that their formation is organised by a robust developmental program. Jhaveri and colleagues examined the role played by Roundabout (Robo) – the receptor for the diffusible ligand Slit – during the positioning of glomeruli (p. 1903). They found that different populations of olfactory sensory neurons express different combinations of Robo, Robo2 and Robo3 at different times during development. Furthermore, disrupting the expression of these proteins in specific neurons results in changes in glomerular organisation. They also showed that by manipulating Slit levels, they could alter the terminal positioning of sensory neurons. The researchers suggest that the combinational code of Robo receptors and their response to Slit levels guides sensory neurons to unique positions in the olfactory lobe.

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Related articles in Development:

Positioning sensory terminals in the olfactory lobe of Drosophila by Robo signaling

Dhanisha Jhaveri, Sumiti Saharan, Anindya Sen, and Veronica Rodrigues
Development 2004 131: 1903-1912. [Abstract] [Full Text]  

This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Related articles in Development Similar articles in this journal Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via Google Scholar Google Scholar Search for Related Content Social Bookmarking                         What's this?