spacer gif spacer gif spacer gif spacer gif ARCHIVE ANNOUNCEMENT! spacer gif
QUICK SEARCH:   [advanced]


spacer gif
     Home     Help     Feedback     Subscriptions     Archive     Search     Table of Contents    

First published online April 22, 2004

Development 131, 902e (2004)
© The Company of Biologists Limited
This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Related articles in Development
Right arrow Similar articles in this journal
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Search for Related Content

In this issue

Squid and gurken: a complex interaction


During Drosophila oogenesis, two different isoforms of Squid (Sqd) – a heterogeneous nuclear ribonucleoprotein (hnRNP) – regulate the localisation and translation of gurken (grk) mRNA, whose restriction to the dorsal anterior region of the oocyte is crucial for establishing the dorsoventral axis. On p. 1949, Goodrich and colleagues investigate the mechanism by which Sqd regulates grk expression. They show that another hnRNP, Hrb27C, together with the protein Ovarian tumour (Otu), interacts with Sqd to localise grk mRNA. Unexpectedly, hrb27C, sqd and otu mutants also have defective nurse-cell polytene chromosome dispersion. Normally, the visible polytene chromosomes of nurse cells disperse during early oogenesis, possibly to facilitate rapid ribosome synthesis. The researchers go on to propose a model in which Sqd, Hrb27C and Otu function in a single RNP complex that spatially and temporally regulates different RNA targets in different cell types.


Related articles in Development:

Hrb27C, Sqd and Otu cooperatively regulate gurken RNA localization and mediate nurse cell chromosome dispersion in Drosophila oogenesis
Jennifer S. Goodrich, K. Nicole Clouse, and Trudi Schüpbach
Development 2004 131: 1949-1958. [Abstract] [Full Text]  




This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Related articles in Development
Right arrow Similar articles in this journal
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Search for Related Content