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First published online December 8, 2004

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FGF threshold for lung specification

Many of the factors that control branching morphogenesis in the developing lung have been identified but much less is known about how the multipotent endoderm of the ventral foregut becomes committed to a pulmonary fate. On p. 35, Serls and colleagues report that a concentration threshold of fibroblast growth factors (FGFs) produced by the cardiac mesoderm patterns the foregut endoderm into lung and liver. They show that in mouse tissue explants, cardiac mesoderm induces the expression of NKX2.1, the earliest known marker of respiratory epithelium, and of later lung-specific markers in the ventral endoderm. An exogenous source of FGF1 and FGF2 can replace the requirement for cardiac mesoderm: low FGF concentrations activate liver-specific genes; higher concentrations activate lung-specific genes. Finally, other results indicate that signalling through FGFR4 is involved in lung specification.

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Different thresholds of fibroblast growth factors pattern the ventral foregut into liver and lung

Amanda E. Serls, Shawna Doherty, Pankhuri Parvatiyar, James M. Wells, and Gail H. Deutsch
Development 2005 132: 35-47. [Abstract] [Full Text]  

This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Related articles in Development Similar articles in this journal Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via Google Scholar Google Scholar Search for Related Content Social Bookmarking                         What's this?