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Fig. 3. Patterning phenotypes of the MtPtch1;Ptch1^-/-, MtPtch1;Ptch1^-/-;Hhip1^+/- and MtPtch1;Ptch1^-/-;Hhip1^-/- neural tube at E10.5. (A-X) Immunofluorescence of neural tube sections. Genotypes of the embryos and antibodies as indicated in each panel. Sections in A-P are aligned at the same ventral position (bottom). Sections in Q-X are aligned at the same dorsal position (top). (Y) Quantification of Foxa2⁺ cells in wild-type, MtPtch1;Ptch1^-/-, MtPtch1;Ptch1^-/-;Hhip1^+/- and MtPtch1;Ptch1^-/-;Hhip1^-/- embryos. (Z) Quantification of the size of each progenitor domain along the DV axis in cell diameters in wild-type, MtPtch1;Ptch1^-/-, MtPtch1;Ptch1^-/-;Hhip1^+/- and MtPtch1;Ptch1^-/-;Hhip1^-/- embryos. d, dorsal domain. (a) Representation of the size of each progenitor domain along the DV axis as a percentage of the total DV length of the neural tube. Scale bar: 50 µm.

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