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Fig. 1. Mutations and structure of the retn gene. The structure of the
retn gene is shown (introns not to scale), including the previously
undetected exon 1-4 and exon 1-6 splice variants. Positions and structures
derived from Gregory et al. (Gregory et
al., 1996) and from our analysis of the genomic sequence of the
region. The regions shown in white encode the extended ARID box DNA-binding
domain. The viable ('retn class') alleles
retnRO44, retnz2-428 and
retnRU50 encode missense mutations within the ARID box.
Embryonic lethal ('dri class') alleles retndri1
and retndriB142 encode nonsense mutations. P-element
insertions retndri7 and retndri8 map
in or near retn exon 1. retn-Gal4 insertions were created by
targeted transposition into the retndri7 and
retndri8 positions
(Shandala et al., 1999).