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Fig. 5. Chx10 is necessary to maintain neuroretinal cell identity. (A) The majority (n=18/24) of Chx10^or-J/or-J (J/J) individuals from a mixed genetic background (129/SvJ;C57BL/6) have a `salt-and-pepper' neuroretinal phenotype consisting of pigmented and non-pigmented cells (arrowhead) and a normal RPE (arrow). (B) A higher magnification view of A clearly shows the cellular pigment phenotype in the NR (arrowhead). The broken white lines indicate the edges of the NR. For comparison, a 129/SvJ Chx10^or-J/or-J non-pigmented NR is shown in Fig. 4A,B. (C) A subset of Chx10^or-J/or-J mice (n=2/24) from a mixed genetic background have a PML (arrowhead) instead of a NR and a normal RPE (arrow). (D) An enlargement of (C) focusing on the PML (arrowhead). Scale bars: 50 µm in A,C; 12.5 µm in B,D.

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