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Fig. 2. Histology of Hand1 mutant hearts. (A) Hearts from wild-type (a) and Hand1 lacZ/loxP; {alpha}MHC::Cre (mutant) (b-d) neonates were sectioned and stained with Hematoxylin and Eosin. A mutant heart with a membranous VSD (black arrowhead) is shown in b. A mutant heart with thickened AV valves is shown in c. A mutant heart with overriding aorta (asterisk) is shown in d. Higher magnification of the AV valves from wild type (e) and mutant (f) hearts. Arrows indicate the leaflets of the valves. (B) Hearts from wild-type (a,d) and Hand1lacZ/loxP; {alpha}MHC::Cre (mutant) (b,c,e,f) embryos at E11.5 (a-c) and E13.5 (d-f) were sectioned and stained with Hematoxylin and Eosin. The mutant hearts show poorly organized ventricular septa and left ventricular hypoplasia. Immature endocardial cushions are also seen in mutant hearts at E13.5. Arrowheads indicate the interventricular septum.





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