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Fig. 6. Dysregulation of cardiac genes in Hand1 and Hand2 mutant embryos. (A) Transcripts for Anf, Mlc2v, Cited1, connexin 40 (Cx40) andTbx5 were detected by whole-mount in situ hybridization on wild-type and Hand1 cardiac-KO/KO embryos at E10.5. The reduction in Cited1 expression in the LV and the upregulation of Anf in the RV of mutant embryos is shown. lb, limb bud; lv, left ventricle; rv, right ventricle. (B) Transcripts for Anf, connexin 40 and Tbx5 were detected by whole-mount in situ hybridization on wild-type and Hand1 cardiac-KO/KO; Hand2 KO/+ embryos at E9.5. Anf expression is absent in the LV of the mutant embryo (arrows). Expression of Cx40 in the LV of the mutant is also lost (arrows), but normal levels of expression are maintained in the dorsal aorta and vasculature. Expression of Tbx5 is unaffected in the heart of the mutant (arrows).





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