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Fig. 3. ß-Catenin promotes chondrocyte proliferation and maturation. (A-C') In situ hybridization using 35S-labeled riboprobes against Col1a1 (A,A'), Ihh (B,B') or Ptc1 (C,C') on sections of E15.5 humeri of wild type (A-C) or Dermo1Cre; ß-cateninc/c (CKO) embryos (A',B',C'). H, hypertrophic chondrocytes. M, marrow cavity. Arrow in A' denotes a cluster of hypertrophic chondrocytes. Arrows in C and C' indicate the perichondrium. (D) BrdU labeling index of chondrocytes in the humeri of E15.5 wild type (WT) or Dermo1Cre; ß-cateninc/c (MT) embryos.





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