QUICK SEARCH:   [advanced] Author: Keyword(s):
Home     Help     Feedback     Subscriptions     Archive     Search     Table of Contents

First published online April 27, 2005

This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Related articles in Development Similar articles in this journal Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via Google Scholar Google Scholar Search for Related Content Social Bookmarking                         What's this?

Transporting food into growth

Cell and tissue growth can be altered during development by an embryo's nutritional status. Varying nutrient levels cause changes in intracellular amino acid levels and trigger signalling from the insulin receptor (InR) pathway, resulting in the subsequent modulation of intracellular TOR kinase activity. On p. 2365, Goberdhan et al. report two new Drosophila proton-assisted amino acid transporters (PATs), CG3424 (also called PATH) and CG1139, that modulate tissue growth in many non-endocrine tissues. These PATs genetically interact with TOR and with other InR signalling components. CG3424, which is widely expressed, also activates a TOR target in an amino acid-dependent manner when expressed in a Xenopus oocyte system. Surprisingly, it has a very low capacity for transporting amino acids, but a high affinity compared with CG1139 and other mammalian PATs, suggesting that growth control via this process is conserved but does not require bulk amino acid transport into a cell.

CiteULike    Complore    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter    What's this?

Related articles in Development:

PAT-related amino acid transporters regulate growth via a novel mechanism that does not require bulk transport of amino acids

Deborah C. I. Goberdhan, David Meredith, C. A. Richard Boyd, and Clive Wilson
Development 2005 132: 2365-2375. [Abstract] [Full Text]  

This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Related articles in Development Similar articles in this journal Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via Google Scholar Google Scholar Search for Related Content Social Bookmarking                         What's this?