QUICK SEARCH:   [advanced] Author: Keyword(s):
Home     Help     Feedback     Subscriptions     Archive     Search     Table of Contents

First published online April 27, 2005

This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Related articles in Development Similar articles in this journal Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via Google Scholar Google Scholar Search for Related Content Social Bookmarking                         What's this?

Actin reorganisation during morphogenesis

The Rho family of small GTPases function in many morphogenetic processes that shape an embryo. Their activity is partly modulated by RhoGAP proteins, which switch RhoGTPases to an inactive state. By searching for genes that regulate Drosophila embryo morphogenesis, Denholm et al. have discovered that the crossveinless-c (cv-c) gene encodes a RhoGAP that is expressed in, and is required by, multiple embryonic tissues undergoing morphogenesis, such as the Malpighian tubules (MpTs) and the epidermis during dorsal closure (see p. 2389). Genetic interactions between cv-c and RhoGTPase mutants indicate that the small GTPases, Rho1, Rac1 and Rac2, are Cv-c substrates. The authors' loss- and gain-of-function studies reveal that Cv-c regulates actin cytoskeleton dynamics during MpT convergent extension movements. From these and other data, they conclude that Cv-c functions to organise the actin cytoskeleton in tissues undergoing morphgenesis by regulating the activity of specific RhoGTPases.

CiteULike    Complore    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter    What's this?

Related articles in Development:

crossveinless-c is a RhoGAP required for actin reorganisation during morphogenesis

Barry Denholm, Stephen Brown, Robert P. Ray, Mar Ruiz-Gómez, Helen Skaer, and James Castelli-Gair Hombría
Development 2005 132: 2389-2400. [Abstract] [Full Text]  

This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Related articles in Development Similar articles in this journal Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via Google Scholar Google Scholar Search for Related Content Social Bookmarking                         What's this?