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Fig. 9. A summary of (A) gene expression changes in Gbx2 mutants and (B)
proposed interactions of Gbx2 with other genes known to affect inner
ear development. (A) Anterior views of a schematic
Gbx2+/– and Gbx2-/- right
otocyst. Gbx2 is expressed in the dorsomedial domain (blue);
Lfng is expressed in the anteroventral lateral domain that expands
medially (orange); and Otx2 is expressed in the ventral
posterolateral domain (yellow) that is complementary to the Lfng
domain and non-abutting to the Gbx2 domain. In a homozygous mutant,
there is a loss of Wnt2b expression (purple) and Dlx5
expression dorsomedially (not shown), as well as an expansion of Otx2
expression domain ventromedially (yellow color). (B) Possible relationships of
Gbx2 with other genes in the hindbrain and inner ear. Arrows do not
imply direct interactions.
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