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Fig. 5. D-mib promotes the signaling activity of DSL ligands. Shown are wing imaginal discs doubly stained for Cut (A-F) and DNA (G-L); only the wing pouch region is shown in (A-F). (A,G) Wild type. Expression of Cut at the wing margin is denoted with two arrowheads, and the ventral (V) and dorsal (D) regions of the wing pouch are marked. (B,H) dpp-Gal4>UAS-Delta disc is strongly overgrown (compare disc sizes of G and H). A strong ectopic margin is seen in the dorsal wing pouch (D) posterior to the dpp-Gal4 domain. (C,I) dpp-Gal4>UAS-Delta, UAS-D-mib disc is similarly overgrown; however, strong ectopic margins are now induced in the ventral compartment (V) both anterior and posterior to the dpp-Gal4 domain. (D,J) dpp-Gal4>UAS-Delta, UAS-D-mib{Delta}RF shows complete suppression of Delta-induced disc overgrowth (compare J with H), and complete inhibition of Delta-induced margin development. In addition, there is a large gap in the endogenous wing margin in the dpp-Gal4 domain (D, asterisk), as seen with UAS-dpp-Gal4>UAS-D-mib{Delta}RF discs (see Fig. 6O). (E,K) dpp-Gal4>UAS-Serrate disc is strongly overgrown and shows ectopic ventral margins (V). (F,L) dpp-Gal4>UAS-Serrate, UAS-D-mib{Delta}RF shows complete suppression of Serrate-induced disc overgrowth and margin induction, and a gap in the endogenous wing margin can be seen (F, asterisk).





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