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Fig. 7. Mutual phenotypic suppression of wild-type Neur and D-mib proteins with their RING-deleted counterparts. Shown are adult wings of the depicted genotypes, with a focus on wing vein determination and wing margin development. (A) dpp-Gal4/+ wing. Arrowhead denotes the anterior crossvein and asterisk marks the distal wing margin. (B) dpp-Gal4, UAS-neur wing is mostly wild type. (C) dpp-Gal4, UAS-D-mib wing shows mild wing vein loss (arrowhead). (D) dpp-Gal4, UAS-neur{Delta}RF wing exhibits a distal wing notch (asterisk) and a very mildly thickened L3 vein. Wing notching induced by neur{Delta}RF is completely suppressed by the co-expression of UAS-neur (E, asterisk), as well as by UAS-D-mib (F, asterisk); wing vein loss is often observed in the latter (F, arrowhead). (G) dpp-Gal4, UAS-D-mib{Delta}RF wing displays an enormous wing notch (asterisk) and a severely thickened L3 wing vein remnant (arrow). Both phenotypes are partially suppressed by the co-expression of one copy of UAS-neur (H, arrow and asterisk) and are almost completely suppressed by the co-expression of two copies of UAS-neur (I, arrow and asterisk). Note that some wing vein loss is even evident in the latter genotype (I, arrowhead).





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