spacer gif spacer gif spacer gif spacer gif spacer gif
QUICK SEARCH:   [advanced]


spacer gif
     Home     Help     Feedback     Subscriptions     Archive     Search     Table of Contents    

Right arrow Help viewing high resolution images
Right arrow Return to article
(Downloading may take up to 30 seconds.
If the slide opens in your browser, select File -> Save As to save it.)
Click on image to view larger version.



Fig. 4. Stereociliary bundles of vestibular hair cells of mgRb:Rb-/- mutants at birth, as shown by espin-immunostaining. (A) Espin is localized to HC stereocilia of control utricules. (B) In mutants, espin-positive HCs are situated throughout the thickened utricular sensory epithelium. Several HCs at the surface show abnormal bundles. (C,D) High magnification views show HCs with aberrant stereocilia in the utricle and in the adjacent mesenchyme (arrow) of mutants. (E,F) In contrast to controls, mutants show espin-stained HCs at different levels of the ampullary sensory epithelium. HCs in the mesenchyme are also espin positive (arrow). (G,H) In addition to the distinct bundle abnormalities, stereociliary bundle morphologies comparable with controls are seen in some HCs of mutants, especially in ampullae. Abbreviations: wt, wild type; ut; utricle; amp, ampulla; SE, sensory epithelium; ME, mesenchyme; LU, lumen. Scale bar: 70 µm for A-F; 60 µm for G,H; 30 µm for C,D.





Right arrow Return to article