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Fig. 1. The majority of patched mutant mice have ectopic cells in their
cerebellum before they develop tumors. Cerebella from a 6-week-old wild-type
mouse (A), a 6-week-old patched+/– mouse (B) and a
12-week-old patched+/– mouse with a tumor (C) were
fixed and stained with X-gal. Tumors (arrow in C) are found in 15-20% of
mutant mice between 10-25 weeks of age; these tumors express high levels of
the mutant patched allele, which carries the ß-galactosidase
gene. At earlier ages, >50% of patched mutant mice have ectopic
ß-galactosidase-expressing cells (arrowheads in B). Background X-gal
staining was not detected in the cerebellum of adult wild-type mice (A).
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